The University of Iowa High Throughput Screening Facility (UIHTS) is a high throughput platform that integrates robotics, detection systems and chemical /biologics libraries. The objectives are using scalable screening approaches to foster hit and lead generation for drug discovery and development, and to facilitate molecular probe discovery for mechanism of action (MOA) studies of chemical biology. So it enables scientists to translate their scientific breakthroughs into the medicines of tomorrow. As a university core facility, UIHTS strives to provide highly flexible screening services, project management, and assay/technology development for investigators across campus as well as off-campus.
UIHTS facility offers the following services:
1) Assay adaption/development: from bench assay/idea to high throughput screening ready assay, including assay design/development, assay adaption and validation
2) High Throughput Screening: from scalable screen, pilot screen, primary screen, to secondary screen
3) Compound Collections: from copies of the libraries, cherry-picking collections, to dose-response compound plates
4) Data analysis: using specific software for data analysis of high throughput screening and image analysis of high content imaging.
5) Grant assistance: from letter of support, description of the instruments and compound collections, to consultation on common HTS preliminary result requirements.
6) Follow-up services: connection and consultation with experts on medicinal chemistry (hit-to-lead, lead optimization, drug development), PK/PD, pre- and clinical trials, and potential translational studies.
7) Project management support: from electronic notebook, project management, to data management
UIHTS facility service policies: